#135 Guideline Directed Medical Therapy Part II: 5 Pearls Segment

36m | Sep 20, 2023

With progressing CKD & HFrEF, what GDMT medications can you start, continue or stop? What does the data on hydralazine/isosorbide tell us and what does it NOT tell us? What are the pros and cons of starting GDMT inpatient versus outpatient? Do you still keep patients on GDMT once their EF recovers? 

Sponsors: Hellofresh | Pranay's Effective Living Formula Course

Pranay's Free Masterclass (Sept 20 and 27th at 5pm PST)

CME : || Show Notes & Transcript


  • 01:54 Pearl 1 – Recap of GDMT and CKD
  • 09:15 Pearl 2 – Hydralazine and Isosorbide Dinitrate 
  • 20:59 Pearl 3 – Ivabradine 
  • 25:47 Pearl 4 – Inpatient vs Outpatient Initiation of GDMT
  • 30:55 Pearl 5 – Ejection Fraction Recovery 


Tags: IMCore, CoreIM, hydralazine, heart failure reduced ejection fraction, HFmrEF, HFimpEF, chronic kidney disease, cardiology

Find the best disability insurance for you:

Our Sponsors:
* Go to For a great deal: Use the code coreim50

Advertising Inquiries:

Privacy & Opt-Out:
Core IM | Internal Medicine Podcast