University of Minnesota Medical School finds Metformin Reduced COVID-19 Death Risks in Women #23
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Links:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395819/
https://clinicaltrials.gov/ct2/show/NCT04510194
https://www.thelancet.com/journals/lanhl/article/PIIS2666-7568(20)30033-7/fulltext
https://www.medscape.com/viewarticle/935724
https://medicalxpress.com/news/2020-12-metformin-covid-death-women.html
The University of Minnesota Medical School and the United Health Group researchers found that metformin was associated with significantly reduced COVID-19 death risks in women in one of the world's largest observational studies of COVID-19 patients.
Diabetes and COVID-19
Severe COVID-19 outcomes for people with diabetes have been widely observed, including greater risk of intensive care unit admission, intubation for mechanical ventilation and death,
These outcomes could possibly be related to less effective glycemic or blood sugar control in these patients.
Metformin is an established, generic medication for managing blood sugar levels in patients with type 2 diabetes.
It also reduces inflammation proteins like TNF-alpha that appear to make COVID-19 worse.
The Study
The team analyzed 6,256 individuals with type 2 diabetes or obesity who were hospitalized with COVID-19 and assessed whether or not the use of metformin was associated with decreased mortality
The investigators identified 2,333 adults who had filled 90-day metformin prescriptions within 12 months of their COVID-19 diagnosis (with a mean age 73), and 3,923 non-users of Metformin (with a median age of 76)
They then assessed the associations between home metformin use and risk of in-hospital death from COVID-19.
The results
They found an association that women with diabetes or obesity, who were hospitalized for COVID-19 disease and who had filled a 90-day metformin prescription before hospitalization, had a 21% to 24% reduced likelihood of mortality compared to similar women not taking the medication.
There was no significant reduction in mortality among men.
Carolyn Bramante, MD, MPH, the principal investigator and assistant professor in the Department of Medicine at the University of Minnesota Medical School said "Observational studies like this cannot be conclusive, but contribute to growing bodies of evidence. Seeing a bigger association with protection in women over men may point towards inflammation reduction as a key way that metformin reduces risk from COVID-19. However, more research is needed,"
She also said:
"A large database covering different geographic areas is rarely available. We were fortunate to have the opportunity to do this research alongside UnitedHealth Group."
Deneen Vojta, MD, executive vice president of Enterprise Research and Development at UnitedHealth Group said, "While effective therapies to mitigate the harm of the SARS-CoV-2 virus are being developed, it is important that we also look to, and evaluate commonly used medications with good safety profiles for their potential to combat the virus,"
New Drug Application
Christopher Tignanelli, MD, assistant professor in the Department of Surgery at the University of Minnesota Medical School and Carolyn Bramante, together have submitted an investigational new drug application to the Food and Drug Administration for use of metformin for COVID-19 treatment and prevention.
The FDA approved this application.
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