SHOW / EPISODE

The New Rules of Longevity: Pept*des, Perimenopause & Flexibility for Building a Better Joyspan in Women After 40 with Dr. Melissa Grill-Petersen

Season 15 | Episode 368
1h 1m | Nov 2, 2026

What if longevity isn't just about living longer, but creating a life you genuinely love living? In this fascinating conversation, Dr. Melissa Grill-Petersen challenges the way we think about healthspan, exploring everything from biohacking and health data to the often overlooked concept of joyspan. We dive into how to work with your body's changing demands, why flexibility is essential during perimenopause, and how to distinguish hormonal changes from cortisol and thyroid dysfunction. Plus, we explore the future of pept*des, why foundational health practices should always come first, and how we can support cellular health for the long haul. Get ready for a fresh perspective on what it really means to age well, thrive, and flourish at every stage of life!

Dr. Melissa Grill-Petersen is a pioneering global thought leader shaping the future of longevity, healthspan, and human flourishing. She is the Founder and CEO of Human Longevity Global and Co-Founder and President of Pept*de University, where her work spans clinician education, regenerative and metabolic medicine, research, and the development of new models for extending human health and capacity. Creator of the Healthspan Model, Dr. Melissa works beyond the clinic, advising companies, boards, governments, and global initiatives on how we design healthier people, organizations, and communities. Her work with the Smart Cities Council is helping bring healthspan into the conversation around the cities and societies of the future. She is a TEDx speaker, educator, and best-selling author of The Codes of Longevity, known for translating complex emerging science into powerful frameworks for living better today—and longer tomorrow. 

SHOW NOTES:

0:39 Welcome to the podcast!

2:37 About Dr. Melissa Grill-Peterson

3:02 Welcome her to the show!

3:57 What does “longevity” actually mean?

6:42 The introduction of biohacking & data

7:40 Sick-care to health-care to well-care

9:58 What data DOESN’T give us

12:15 “Joyspan” vs Well-being

14:35 How your body responds to demands

17:42 ACT Method & saying no

19:54 When something no longer works for you

23:05 Should we live like the Blue Zones?

27:56 Practicing flexibility in Perimenopause

30:48 How your biology changes during this transition 

35:08 Cortisol & Thyroid dysfunction vs Menopause

38:19 Foundations before p@ptides

45:23 Dosing & cycling p@ptides

49:30 The future of p@ptides

52:58 Supporting cellular health

58:23 Her final piece of advice

59:38 My Peptide University

1:00:52 Thanks for tuning in!

RESOURCES:

Human Longevity Global

humanlongevityinstitute.com

mypeptideuniversity.com

Instagram: @drmelissagp



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Renee Belz & Lauren Sambataro
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